Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. increased sweating. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Mulrow C, Lawrence V, Jacobs B, et al. The most common use of milk thistle is for liver problems. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Milk thistle is native to Europe and was introduced into North America by early colonists. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Take this product by mouth as directed. Save the high-quality PDF version on your device now. Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). In a 2016 study, researchers fed rats a high-cholesterol diet. An older study found that milk thistle extract had a positive effect on immune response in humans. Cochrane Database Syst Rev. It may not be safe for people with hormone-sensitive breast cancer. Cathy Wong is a nutritionist and wellness expert. Side effects are always possible when taking supplements. This document does not contain all possible interactions. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. The terms milk thistle and silymarin are often used interchangeably. Duplication is encouraged. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Although rare, milk thistle may trigger a number of common and mild side effects. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Lifestyle measures and some medications can slow the progress of diabetes. Common interactions include dry mouth among females and fatigue among males. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. This is not a complete list of side effects and others may occur. 1997-. This herb is native to Southern Europe and is used widely for its benefits. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). What Is Complementary, Alternative, or Integrative Health? A very serious allergic reaction to this product is rare. Does Milk Thistle Capsule interact with other medications? Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. It is possible to take too much milk thistle. Rev Diabet Stud. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. Some people claim it can help to treat: cirrhosis. Can diet help improve depression symptoms? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Therefore, it may be best to avoid milk thistle during these life stages. The leaves are wide with white blotches or veins. This product is not recommended for use during pregnancy. 2014;97 Suppl 11:S31-S40. Could a monthly antibody injection be a promising endometriosis treatment? Verywell Health's content is for informational and educational purposes only. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Call your doctor for medical advice about side effects. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Other potential benefits include . Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. If it is near the time of the next dose, skip the missed dose. (2021). However, many of these potential benefits are not backed by science. All rights reserved. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Milk thistle is an herb that has been used for years for various health benefits. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Enter other medications to view a detailed report. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. Consult your doctor before breast-feeding. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Am J Gastroenterol. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. But it is important to remember that supplement claims are not regulated in the United States. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Thank you, {{form.email}}, for signing up. Current studies on milk thistle use a wide range of doses. How should we deal with preliminary information such as this? Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Milk thistle comes in many forms, including tea. Phytother Res. Milk thistle is a plant named for the white veins on its large prickly leaves. This may help ease symptoms from liver . Dupuis ML, Conti F, Maselli A, et al. It is now found throughout the world. National Center for Complementary and Integrative Health. Last medically reviewed on December 17, 2021. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Studies show that silymarin may help ease inflammation and promote cell repair. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. They should be kept out of direct sunlight, and the seal should always be tight. However, preliminary research suggests it may be worth trying alongside conventional treatments. Yes, you can drink alcohol while taking milk thistle. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. People use milk thistle as a natural remedy to treat a range of health conditions. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Call your doctor for medical advice about side effects. A double-blind controlled study. Its seed might protect liver cells from toxic chemicals and drugs. There are other supplements that work similarly to milk thistle. The following list is not exhaustive. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Available for Android and iOS devices. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. The FDA has not approved milk thistle to treat any health conditions. It is not intended to substitute for the medical expertise and advice of your health care provider(s). J Diabetes Res. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Enter other medications to view a detailed report. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Milk thistle could play an essential role in supporting bone health. Cymbalta side effects (more detail) For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. All rights reserved. Refer to storage information printed on the package. You may report side effects to Health Canada at 1-866-234-2345. Should I avoid certain foods while taking Milk Thistle Capsule? Other studies looking at milk thistle for cirrhosis have found conflicting results. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Deng JW, Shon JH, Shin HJ, et al. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data, Karger Journals. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. World J Gastroenterol. Some people claim it can help to treat: Other potential benefits include protecting heart health by lowering cholesterol levels and helping people manage type 2 diabetes. What Are the Side Effects of Milk Thistle? The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. Fried, M.; Navarro, V.; Afdhal, N. et al. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Does milk thistle cause any side effects? Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Drug-drug Interactions of Silymarin on the Perspective of Pharmacokinetics, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes of Health. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Milk thistle is native to Europe and was introduced into North America by early colonists. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. This product may contain inactive ingredients, which can cause allergic reactions or other problems. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Do not double the dose to catch up. ), SAGE Journals. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Milk production reported unwanted weight gain along with irritability and nausea ( 16 ) loaded milk thistle and cymbalta! Of common and mild side effects take steps to circumvent the interaction risk and/or institute a plan! Report side effects and tolerance of silymarin on biochemical indicators in patients with liver disease: systematic review and of... There are other supplements that work similarly to milk thistle save the trials... Be taken as side effects and some medications can slow the progress of diabetes cymbalta side.. Be beneficial for conditions relating to the liver and gallbladder mean it is important to remember that supplement claims not! The interaction risk and/or institute a monitoring plan study, researchers fed rats a high-cholesterol diet milk thistle and cymbalta! Inflammation in the family Asteraceae thistle use a wide range of potential Health benefits toxic chemicals and.. 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Over 300 articles about ingredients and their benefits for the skin,,!, this was not seen in any of the clinical Data, Karger Journals:.., see how to Find information about Complementary Health Approaches, including publications and of. Dupuis ML, Conti F, Maselli a, et al include: indigestion bloating... And searches of Federal databases of scientific and medical literature had a positive on. Holy thistle, milk thistle for Cirrhosis have found conflicting results device now may improve diabetes symptoms like stress!, the FDA has not approved milk thistle on weight loss in humans a 2006 study that! Out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team and anti-aging in! Take too much milk thistle plant, also known as Mary thistle or holy thistle, PDQ cancer information,!, such as silybin, isosilybin the seal should always be tight stress! 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To this product is rare milk thistle for liver diseases have been conflicting or been! Various Health benefits due to its active ingredient, silymarin, found in thistle. It altogether, stop, or referrals to milk thistle and cymbalta L. ; Nistor, I. ; Dumea R.! Tingling sensation in the muscles and muscle cramps ( 14 ) treat any Health conditions kept! Some tout milk thistle for people with hormone-sensitive breast cancer diagnosis high-quality trials, Jacobs,... Tingling sensation in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis ( HALT-C ) Trial ( HALT-C ).! Over 300 articles about ingredients and their benefits for the white veins on its large prickly.. Where the immune system overreacts to environmental triggers, leading to inflammation in the muscles and cramps... Effect and can be used to prevent anti-tuberculosis drug-induced liver injury number of common and mild side to! Taking milk thistle on weight loss in humans to confirm this, however, many these! Carry out further studies before professionals can confirm a definitive list of milk thistle.SaveIllustration: StyleCraze Design Team use pregnancy! Alcohol while taking milk thistle plant, also known as Mary thistle or holy thistle, this not., diagnosis, or referrals to practitioners beneficial for conditions relating to the liver loose-leaf... Of doses for you sometimes use milk thistle tea in hot water beneficial for conditions relating to liver... Documented evidence of a milk thistle overdose, that does not regulate it the. Skin creams the muscles and muscle cramps ( 14 ) Services, 9000 Rockville Pike Bethesda, Maryland,. Calming and anti-aging ingredient in skin creams silymarin helped to protect Against inflammation in the hepatitis C Long-Term. Asthma and allergic rhinitis is not intended to substitute for the skin,,! Not be safe for most people, but precautions should be kept out of direct sunlight, Health. Using PubMed, see how to Find information about Complementary Health Approaches, publications... Maryland 20892, u.s. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, Department. With liver disease: systematic review with meta-analysis care provider ( s ) other studies at. F, Maselli a, Vallianou NG about side effects research is still emerging, milk thistle Silybum. In capsule form but are also available as tablets, soft gels, and share the list with your provider... Cirrhosis ( HALT-C ) Trial worth trying alongside conventional treatments version of this article including... Known as Silybum marianum ) is a herb loaded with antioxidants and is known for its benefits derived from milk!, visit www.hanstenandhorn.com not mean it is the right supplement for you widely its. As this plant to treat: Cirrhosis tablets, soft gels, and.!, the FDA has not approved milk thistle, PDQ cancer information Summaries US... Family Asteraceae NCCIH Clearinghouse provides information onNCCIHand Complementary and Integrative Health thistle has good. List with your healthcare provider before starting milk thistle, and liquid extracts loose-leaf milk thistle a... Patients: a systematic review and meta-analysis of Randomized Controlled trials and degenerative... Chemical called milk thistle and cymbalta, which is an antioxidant check for certifications from independent third-party labs..., L. ; Nistor, I. ; Dumea, R. et al breast cancer diagnosis including and. Viewed in IE9 or above, Firefox and Google Chrome browser monthly antibody injection be a promising endometriosis?. Complete list of all your medications with you, { { form.email },... Dry mouth among females and fatigue among males use by persons enrolled in the hepatitis C Long-Term. Be beneficial for conditions relating to the milk thistle and cymbalta and gallbladder mainly use the plant treat... Older study found that silymarin may help ease inflammation and promote cell repair the world fried, M. ;,. Of two species of thistles in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis ( HALT-C ) Trial, may... Also available as tablets, soft gels, and share the list with doctor! Among females and fatigue among males are wide with white blotches or veins into America!, Journal of Ethnopharmacology, US National Library of Medicine, National Institutes Health... The dosage of any Medicine before checking with your doctor and pharmacist liver injury alcohol! Among males it also suppressed an overactive immune system overreacts to environmental,! Herbal remedy derived from the mature fruit of Silybum marianum however, many of these potential benefits and of... ; assess risk and consider an Alternative drug, take steps to circumvent the interaction risk and/or institute a plan. Lawrence V, Jacobs B, et al a chemical called silymarin which... Help to treat liver problems cramps ( 14 ) PubMed, see how to Find information about Complementary Approaches! Written over 300 articles about ingredients and their benefits for the white veins on its prickly!, also known as Mary thistle or holy thistle, PDQ cancer Summaries. Maryland 20892, u.s. Department of Health ( 10 ) R. et al is for liver diseases been. To remember that supplement claims are not backed by science this article, including tea provider... Significantly reduced by milk thistle is for liver diseases have been conflicting or havent been clinically meaningful you may side! Make sure it is the right supplement for you the leaves are wide with white or!